Winner: 49ers Offense

Sunday's NFL Winners and Losers

Remember last year when the 49ers' offense was barely good enough to get them wins? Now San Francisco's putting up 40-burgers on people. San Francisco beat the Bills, 45-3, on Sunday and had a 300-yard passer (some joker actually predicted that), two 100-yard receivers and a 100-yard rusher for the first time in franchise history. Who cares if it was Buffalo? The 49ers finished with 621 yards of total offense! (AP Photo)

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Week 5 By Jordan Raanan, XFINITY Sports NFL Columnist

When it comes to winners this week, there are the Colts and Chuck Pagano ... and then there is everybody else.

What a feel-good story. Pagano is undergoing treatment for Leukemia. The Colts won for their ailing coach, who spent the afternoon watching Indy stun the Packers from room C23 at the Indiana University Simon Cancer Center. You know Pagano must be well-liked and respected if he was able to push Tom Brady and Peyton Manning out of the headlines. He is and he did.

Pagano and the Colts were this Sunday's biggest winners. Here are the rest of the winners and losers from the weekend:

Jordan Raanan has covered the NFL since 2005. Follow him on Twitter @JordanRaanan, on Facebook or email him at jraanan@hotmail.com.

The opinions expressed are solely those of the author and do not necessarily reflect the views of Comcast.
Winner: Chuck Pa... What a story. The Colts, huge underdogs at home, rallied to beat the Packers, 30-27, as their coach Chuck Pagano watched from a hospital room. Owner Jim Irsay reportedly brought Pagano, who is undergoing treatment for Leukemia, the game ball. This is Cinderella stuff. The Colts won one for their coach. (AP Photo/Michael Conroy)

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Winner: Drew Bre... The Saints' star quarterback broke Johnny Unitas' record by throwing a touchdown pass in his 48th straight game. The Saints also won for the first time this season, 31-24 over the Chargers. Finally something to celebrate in New Orleans. (AP Photo/Bill Feig)

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Loser: Robert Gr... Washington's savior was knocked out of their 24-17 loss to the Falcons with a mild concussion. RG3's first career NFL concussion. He's official now. (AP Photo/Evan Vucci)

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Winner: Tom Brad... Put another one in the win column for Brady in his battle with Peyton Manning for best QB of this era. Tommy's now 9-4 against his rival after playing well in Sunday's 31-21 victory over the Broncos. (AP Photo/Steven Senne)

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Loser: Cincinnat... Just when it looked like the Bengals were a legitimately good team, they do this. Cincy lost at home to the Miami Dolphins, 17-13. (AP Photo/Tom Uhlman)

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Winner: 49ers Of... Remember last year when the 49ers' offense was barely good enough to get them wins? Now San Francisco's putting up 40-burgers on people. San Francisco beat the Bills, 45-3, on Sunday and had a 300-yard passer (some joker actually predicted that), two 100-yard receivers and a 100-yard rusher for the first time in franchise history. Who cares if it was Buffalo? The 49ers finished with 621 yards of total offense! (AP Photo)

The opinions expressed are solely those of the author and do not necessarily reflect the views of Comcast.
Loser: Jacksonvi... Poor Jacksonville. Fans watched the Jags get outscored 38-0 in the second half against the Bears and fall to 0-3 at home. That's bad even for the Jaguars. It's the first time in franchise history Jacksonville has dropped its first three home games. (AP Photo/John Raoux)

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Loser: Tennessee... It's official. The Titans can't stop anybody. After losing 30-7 to the Vikings, they have allowed 30 or more points in all five games this season. That is remarkably bad. (AP Photo/Jim Mone)

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Loser: Kansas Ci... It's never a good look when fans cheer an injury. It's even worse when the injured is on the home team. Chiefs fans cheered when Matt Cassel suffered a head injury in Sunday's 9-6 loss to the Baltimore Ravens. Cassel's teammates weren't happy about it either. (AP Photo/Colin E. Braley)

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Winner: Ahmad Br... A few weeks ago Bradshaw was injured and it looked like Andre Brown might become the Giants' featured back. Not going to happen. Bradshaw rushed for 200 yards after fumbling on his first carry Sunday afternoon in a 41-27 victory over the Browns. (AP Photo)

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Winner: Pittsbur... The Steelers desperately needed a win. They desperately needed a good defensive effort. They received both in a 16-14 win over the visiting Eagles. Pittsburgh was on the verge of falling to 1-3 until Ben Roethlisberger led a game-winning drive that concluded with a Shaun Suisham 34-yard field goal as time expired. All of Pittsburgh exhaled. (AP Photo)

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Loser: Cam Newto... The Panthers quarterback said it all after a 16-12 home loss to the Seahawks: "Cameron Newton didn't play good football today." Nobody is going to argue. Newton completed 12 of 29 passes for 141 yards and no touchdowns. (AP Photo/Bob Leverone)

The opinions expressed are solely those of the author and do not necessarily reflect the views of Comcast.