: 320,454 Violent crime rate
: 1,857 per 100,000 residents
Lying directly in the path of major drug-trafficking routes, St. Louis has been plagued by murders and other violent crimes for years. The crime rate fell 4% last year -- and it's down 50% from the crack epidemic days of the early 1990s -- but St. Louis still ranked fourth in the nation for murders.
(Robert Cohen/MCT/Newscom) More From Forbes
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