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Vetstreet.com: 13 Largest Dog Breeds

Neopolitan Mastiff

You wouldn’t want to run into the Neo, as he’s nicknamed, in a dark alley. His wrinkled, scowling face, plastered onto a massive head, and his massive body are enough to give any evildoer second thoughts — fast! Neopolitan Mastiffs range in height from 24 to 31 inches and weigh 110 to 150 pounds or more.

(Credit: Ron Willbie, Animal Photography)
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