Are you traveling by car? If so, gas will be your biggest expense. You might be surprised to learn how widely gas prices can vary from town to town. Plan ahead and find the best fuel options along your route and at your destination. GasBuddy.com
is one site that can help with this.
If you're flying, make sure you exhaust all of your options for finding cheap airfare. A couple of handy resources: TripAdvisor's SeatGuru
helps you find the best seat on any model of airplane, and Bing Travel's Farecast service
will let you know whether it would be a good idea to buy tickets now or later.