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2. Subway; Milford, Connecticut: $10.6 billion

Number of U.S. locations: 24,885

Footlong subs are now part of Americans’ culinary lexicon thanks to Subway, the sandwich shop that traces its roots back to 1965. While you can indulge in, say, a meatball sub at 9 a.m., most recently the popular franchise operation introduced Fresh Fit egg-white breakfast sandwiches with the likes of steak, black forest ham, and cheese on flatbread and light, wheat English muffins for fewer than 200 calories.

(Credit:© Subway)
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