20. Sigourney Weaver
Sigourney Weaver has been called “the Queen of Sci-Fi” for her roles in some of the most well known Science Fiction films in movie history. Her films have grossed $2,072 billion overall. Weaver may be best known for her role as Ellen Ripley in the “Alien” film series, a role for which she was nominated for an Academy Award. Weaver was also nominated in 1988 for “Gorillas in the Mist” and “Working Girl”. Weaver also appeared in "Avatar", a film hailed by many to be the best of 2010. Her latest film, "You Again," hits theraters next Friday, Sept. 24, 2010.
Highest Grossing Film: Weaver appeared in James Cameron’s Academy Award nominated film “Avatar,” which grossed $759.6 million. (Photo: AP)