Dr. Niles Crane is a Seattle-area psychiatrist and brother to famed KACL radio psychiatrist, Dr. Frasier Crane. Niles is obsessive compulsive, occasionally neurotic, often snobby and highly intellectual. For years, Niles lusted after his father's live-in physical therapist, Daphne Moon. The two eventually married.
David Hyde Pierce played Niles from 1993-2004.—XFINITY Entertainment Staff (Photo: AP/NBC)
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