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Actress Kirstie Alley has always struggled with her weight. After months of hard work, she appeared on Oprah's stage in 2006 to show off her new body in a cranberry bikinis, shocking millions of viewers. (Photo: Harpo Productions)
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Best TV MomentsFrom touching stories to shocking interviews, check out the biggest moments on "The Oprah Show." (AP Photo/Chris Pizzello, file)
The opinions expressed are solely those of the author and do not necessarily reflect the views of Comcast.
Fat Wagon (1988)After four months of dieting, the formerly large host shocks her audience by wearing slim designer jeans and pulling a wagon filled with 67 pounds of fat to represent her lost weight. (AP Photo/Charles Bennet, file)
The opinions expressed are solely those of the author and do not necessarily reflect the views of Comcast.
Michael Jackson ...In 1993, the very private Michael Jackson invited Oprah to the Neverland Ranch for an in depth interview. No topic was off limits and the episode was Oprah;s highest-rated show of all time. They talked about everything: his childhood, love, plastic surgeries, and more. (Photo: Harpo Productions)
The opinions expressed are solely those of the author and do not necessarily reflect the views of Comcast.
John F. Kennedy ...In 1996, for the premiere of her 11th season, Oprah sat down with John F. Kennedy Jr. for a “once-in-a-lifetime” interview. His lush hair, golden boy smile and Camelot personality captivated Oprah and every viewer as John-John spoke about growing up in the White House, his famous girlfriends and his new publication, George. (Photo: Harpo Productions)
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Car Giveaway (20...Oprah celebrated the start of her 19th season by giving the 276 person audience each a new Pontiac, making “You get a car!” a new cultural catchphrase. (Photo: Harpo Productions)
The opinions expressed are solely those of the author and do not necessarily reflect the views of Comcast.
Tom Cruise (2005...One of the most notorious day time episodes in television history, international star Tom Cruise started a public relations nightmare with his erratic couch-jumping appearance. (Photo: Harpo Productions)
The opinions expressed are solely those of the author and do not necessarily reflect the views of Comcast.
James Frey (2006...The public was appalled when news broke that James Frey’s best-selling memoir "A Million Little Pieces" was partly fabricated, but no one was angrier than Oprah, who invited the author onto the show to defend himself against a vengeful daytime TV audience. (Photo: Harpo Productions)
The opinions expressed are solely those of the author and do not necessarily reflect the views of Comcast.
The Big Adventur...Oprah and Gayle King took their friendship to the next level by driving cross-country in a Chevrolet. In the "Big Adventure" we got an intimate view of Oprah in the world and also learn that Oprah hasn’t pumped gas since 1983. (Photo: Harpo Productions)
The opinions expressed are solely those of the author and do not necessarily reflect the views of Comcast.
Obama on Oprah (...Oprah introduced us to her "favorite senator" Barack Obama in 2006. She welcomed Barack and Michelle Obama to the show in May, marking the first time a sitting president has made an appearance on the show. Pictured here during an interview in 2011. (AP Photo/Charles Dharapak)
The opinions expressed are solely those of the author and do not necessarily reflect the views of Comcast.
Kirstie Alley's ...Actress Kirstie Alley has always struggled with her weight. After months of hard work, she appeared on Oprah's stage in 2006 to show off her new body in a cranberry bikinis, shocking millions of viewers. (Photo: Harpo Productions)
The opinions expressed are solely those of the author and do not necessarily reflect the views of Comcast.
Vajayjay (2007)Oprah officially legitimized the word "vajayjay" after swinging from a harness at a resort in Tucson, Arizona. The world was never the same. The revealing moment in which O announced that her "vajayjay was painin" became both an Internet meme and a catchphrase. (AP Photo/Charles Rex Arbogast, file)
The opinions expressed are solely those of the author and do not necessarily reflect the views of Comcast.
Black Eyed Peas ...In 2008, the Black Eyed Peas kicked off Oprah's 24th season with a concert in Chicago. But to Oprah's surprise, the joke was on her. The massive crowd performed a choreographed dance to "I Gotta Feeling," while Oprah watched in shock and amazement. (AP Photo/Kiichiro Sato, File)
The opinions expressed are solely those of the author and do not necessarily reflect the views of Comcast.
Oprah's Half Sis...In January 2011, Oprah told us a family secret she had just found out about months before and introduced the world to her half sister Patricia on the show. (Photo: Harpo Productions)
The opinions expressed are solely those of the author and do not necessarily reflect the views of Comcast.
Hollywood Rags-t...Later Oprah Winfrey became a television host, actress and producer. She has been ranked the richest African American of the 20th century, as well as the greatest black philanthropist in American history. To see some of Hollywood's rags-to-riches stories, click here.
