Like Cruise, Depp is now going through a painful public split. Depp's relationship woes won't hurt his movie-star appeal though. He is the only actor to star in three films that have crossed the $1 billion mark globally. That helps the studios stomach bombs like the recent "Dark Shadows." Depp will next star in "The Lone Ranger" as Tonto.
(Jason Merrit/Getty Images) More From Forbes
: Gallery: Tom Cruise And Katie Holmes Split The Movie Stars With The Most At Stake This Summer Hollywood’s Highest-Paid Actresses The opinions expressed are solely those of the author and do not necessarily reflect the views of Comcast.